Khan WS, Lee E, Lu V, Epanomeritakis I. The Use of Autologous Chondrocyte and Mesenchymal Stem Cell Implants for the Treatment of Focal Chondral Defects in Human Knee Joints—A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences. 2022 April 6.
Davies BM, Carter AR, Brindley DA. A scoping review of the treatment of hypertrophic scars and keloids. Dermatological Reviews. 2022 February 21.
Davies BM, Rawal J, Hull P, Carrothers AD, et al. Major trauma care at a regional trauma centre during the COVID-19 lockdown in England. Annals of The Royal College of Surgeons of England. 2021 December.
Hotham WE, Thompson C, Szu-Ting L, Henson FMD. The anti-inflammatory effects of equine bone marrow stem cell-derived extracellular vesicles on autologous chondrocytes. British Veterinary Association. 2021 November 10. [published online]
Davies BM, Hull P, Ghobrial M, Hussain A, Carrothers AD, Rawal J, Chou D. 1085 Equestrian Related Pelvic and Acetabular Fractures – Experience from a Major Trauma Centre in England. British Journal of Surgery. 2021 October 12. Volume 108, Issue Supplement_6.
Chakrabarti S, Ai M, Wong K, Newell K, Henson FMD, St John Smith E. Functional characterization of ovine dorsal root ganglion neurons reveal peripheral sensitization after osteochondral defect. eNeuro 2021 Sep 17;ENEURO.0237-21.2021. [Online ahead of print]
Loh B, Lim JA, Seah M, Khan WS. Perioperative management of open fractures in the lower limb. Journal of Perioperative Practice 2021 Jul 02 PMID: 34214004.
Carter AR, Davies BM, Brindley DA. Gazing Long into a Clinical and Social Abyss? Treating Hypertrophic Scarring and Keloids. Rejuvenation Research 2021 Jun 08. Volume 24, Number 4
Eldridge SE, Barawi A, Roelofs A, Henson FMD, De Bari C, McCaskie AW, et al. AB0039 Agrin repairs bone and cartilage in vivo. Annals of the Rheumatic Diseases. 2021 June 80(Suppl 1):1052.1-1052.
Waseem S, Lenihan J, Davies BM, Rawal J, Hull P, Carrothers A, Chou D. Low Body Mass Index is Associated with Increased Mortality in Patients with Pelvic and Acetabular Fractures. Injury Reports. 2021 May 04. [Online ahead of print]
Steinberg J, Southam L, Fontalis A, Clark MJ, Jayasuriya RL, Swift D, Shah KM, Brooks RA, McCaskie AW, Wilkinson JM, Zeggini E. Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis. Ann Rheum Dis. 2021 Apr 26;annrheumdis-2020-219760 [Online ahead of print]
Steinberg J, Southam L, Roumeliotis TI, Brooks RA, McCaskie AW et al. Nature Commun. 2021 Feb 26;12(1):1309.
MacKay JW, Nezhad FS, Rifai T, Kaggie JD, Naish JH, Roberts C, Graves MJ, Waterton JC, Janiczek RL, Roberts AR, McCaskie A, Gilbert FJ, Parker GJM. Dynamic contrast-enhanced MRI of synovitis in knee osteoarthritis: repeatability, discrimination and sensitivity to change in a prospective experimental study. Eur Radiol. 2021 Feb 16. [Online ahead of print]
Agarwal N, To K, Khan WS. Cost effectiveness analyses of total hip arthroplasty for hip osteoarthritis: A PRISMA. Int J Clin Pract. 2021 Feb;75(2):e13806
Chan CD, Haagensen EJ, Tensaout HA, Rennie KJ, Gamie Z, Barry J, Birch MA, Gerrand CH, Sohail N, Robson CN, Lunec J, Rankin KS. Co localisation of intra nuclear membrane type 1 matrix metalloproteinase and hypoxia inducible factor 2α in osteosarcoma and prostate carcinoma cells. Oncology Letters. 2021 21(2):1–1.
Hotham WE. A Sprinkling of Gold Dust: Fairytale or Modern Science. Blue Sci 2021 Issue 50
Tomlinson F, Terschuur J, Henson FMD. Use of autologous products for the treatment of joint and soft tissue disease in horses: A systematic review. The Veterinary record. 2021 Jan; 188(2).
Bottle A, Griffiths R, White S, Davies BM, et al. Periprosthetic fractures: the next fragility fracture epidemic? A national observational study. BMJ Open. 2020 Dec 10;10(12):e042371.
Henson F, Lydon H, Birch M, Brooks R, McCaskie A. Using apheresis-derived cells to augment microdrilling in the treatment of chondral defects in an ovine model. J Orthop Res. 2020 Nov 4. [Online ahead of print]
Agarwal N, To K, Mcdonnell S, Khan WS. Clinical and radiological outcomes in robotic assisted total knee arthroplasty: a systematic review and meta-analysis. Journal of Arthroplasty Volume 35, Issue 11, November 2020, Pages 3393-3409.e2.
Kamaraj A, To K, Seah M, Khan WS. Modelling the cost-effectiveness of total knee arthroplasty: A systematic review. J Ortho. 2020 Oct 8;22:485-492.
Lim JA, Loh B, Sylvestor G, Khan W. Perioperative management of distal radius fractures. J Perioper Pract. 2020 Sep 8;1750458920949463. [Online ahead of print]
Mostafa AMHAM, Kyriacou H, Chimutengwende-Gordon M, Khan WS. An overview of the key principles and guidelines in the management of pelvic fractures. J Perioper Pract. 2020 Sep 8;1750458920947358.
Eldridge SE, Barawi A, Wang H, Roelofs A, Henson F, McCaskie AM, De Bari C, et al. Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis. Science Translational Medicine. 2020 Sep 2;12(559) eaax9086
Seefried L, Blyth M, Maheshwari R, McDonnell SM, et al. Penetration of topical diclofenac into synovial tissue and fluid of osteoarthritic knees: a multicenter, randomized, placebo-controlled, pharmacokinetic study. Ther Adv Musculoskelet Dis. 2020 Aug 29;12:1759720X20943088. eCollection 2020.
Chakrabarti S, Ai M, Henson FMD, St. John Smith E. Peripheral mechanisms of arthritic pain: A proposal to leverage large animals for in vitro studies. Neurobiology of Pain. 2020 July 28. [Epub]
To K, Romain K, Mak C, Kamaraj A, Henson F, Khan W. The Treatment of Cartilage Damage Using Human Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Systematic Review of in vivo Studies. Front Bioeng Biotechnol 2020 Jun 11;8:580. [eCollection 2020]
Basyuni S, Ferro A, Santhanam V, Birch MA, McCaskie AW. Systematic scoping review of mandibular bone tissue engineering. Br J Oral Maxillofac Surg. 2020 58(6) 632-642
Migliorini F, Berton A, Salvatore G, Candela V, Khan WS, Longo UG, Denaro V. Autologous chondrocyte implantation and mesenchymal stem cells for the treatments of chondral defects of the knee- a systematic review. Curr Stem Cell Res Ther. 2020;15(6):547-556.
Kaggie JD, Markides H, Graves MJ, MacKay J, Houston G, El Haj A, Gilbert F, Henson FMD. Ultra Short Echo Time MRI of Iron-Labelled Mesenchymal Stem Cells in an Ovine Osteochondral Defect Model. Sci Rep. 2020 May 21;10(1):8451.
Paterson YZ, Cribbs A, Espenel M, Smith EJ, Henson FMD, Guest DJ. Genome-wide transcriptome analysis reveals equine embryonic stem cell-derived tenocytes resemble fetal, not adult tenocytes. Stem Cell Research & Therapy 2020 May 19;11(184)
Chisari E, Rehak L, Khan WS, Maffulli N. The Role of the Immune System in Tendon Healing: A Systematic Review. Br Med Bull. 2020 May 15;133(1):49-64.
Ranmuthu CDS, Ranmuthu CKI, Russell JC, Singhania D, Khan WS. Evaluating the Effect of Non-cellular Bioactive Glass-Containing Scaffolds on Osteogenesis and Angiogenesis in in vivo Animal Bone Defect Models. Front Bioeng Biotechnol. 2020 May 14;8:430.
Bojanic C, To K, Zhang B, Mak C, Khan WS. Human umbilical cord derived mesenchymal stem cells in peripheral nerve regeneration. World J Stem Cells. 2020 Apr 26;12(4):288-302.
Kyriacou H, Khan WS. Important perioperative factors, guidelines and outcomes in the management of hip fracture. J Perioper Pract. 2020 Apr 17:1750458920915656.
JW MacKay, TD Turmezei, J Kaggie, AR Morgan, R Janiczek, WS Khan, S McDonnell, MJ Graves, GM Treece, AW McCaskie, FJ Gilbert. Three-dimensional Surface-based Analysis of Cartilage MRI data in Knee Osteoarthritis: Validation and Initial Clinical Application. JMRI 52(4):1139-1151. PMID: 32447815.
Hotham WE, Henson FMD. The use of large animals to facilitate the process of MSC going from laboratory to patient-‘bench to bedside’. Cell Biology and Toxicology. 2020 Mar 23 [Epub]
Kwan H, Chisari E, Khan WS. Cell-Free Scaffolds as a Monotherapy for Focal Chondral Knee Defects. Materials (Basel). 2020 13(2): E306. PMID: 31936591.
Hernandez PA, Wells J, Usheva E, Nakonezny PA, Barati Z, Gonzalez R, Kassem L, Henson FMD. Early-Onset Osteoarthritis originates at the chondrocyte level in Hip Dysplasia. Sci Rep. 2020 Jan 17;10(1):627.
Chisari E, Rehak L, Khan WS, Maffulli N. Tendon healing in presence of chronic low-level inflammation: a systematic review. Br Med Bull. 2019 Dec 14. pii: ldz035. [Epub ahead of print]
HEALTH Investigators, Bhandari M, Einhorn TA, Guyatt G, Schemitsch EH, Zura RD, Sprague S, Frihagen F, Guerra-Farfán E, Kleinlugtenbelt YV, Poolman RW, Rangan A, Bzovsky S, Heels-Ansdell D, Thabane L, Walter SD, Devereaux PJ. Includes McDonnell SM, Khan WS as collaborators. Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture. N Engl J Med. 2019 Dec 5;381(23):2199-2208.
Katarivas Levy, G., Ong, J., Birch, M., Justin, A. W., & Markaki, A. (2019). Albumin-Enriched Fibrin Hydrogel Embedded in Active Ferromagnetic Networks Improves Osteoblast Differentiation and Vascular Self-Organisation. Polymers. 2019;11(11), 1743-1743.
Chisari E, Yaghmour KM, Khan WS. The effects of TNF-alpha inhibition on cartilage: a systematic review of preclinical studies. Osteoarthritis Cartilage. 2019 Oct 18. pii: S1063-4584(19)31229-4. [Epub ahead of print] Review.
Tanase CE, Qutachi O, White LJ, Shakesheff KM, McCaskie AW, Best SM, Cameron RE. Targeted protein delivery: carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds. Regen Biomater. 2019 Oct;6(5):279-287.
Devoy B, Yaghmour KM, Chisari E, McDonnell SM, Khan W. Perioperative management of renal transplant patients undergoing total joint arthroplasty. J Perioper Pract. 2019 Sep;29(9):270-275.
Katarivas Levy G, Birch MA, Brooks RA, Neelakantan S, Markaki AE. Stimulation of Human Osteoblast Differentiation in Magneto-Mechanically Actuated Ferromagnetic Fiber Networks. J Clin Med. 2019 Sep 22;8(10). pii: E1522.
To K, Crowley C, Lim SK, Khan WS. Autologous adipose tissue grafting for the management of the painful scar. Cytotherapy. 2019 Nov;21(11):1151-1160. Epub 2019 Sep 17. Review.
Berdichevskia A, Birch MA, Markaki AE. Collagen scaffolds with tailored pore geometry for building three-dimensional vascular networks. Materials Letters. 2019 Aug 1; Vol. 248: 93-96
Johnson-Lynn SE, McCaskie AW, Coll AP, Robinson AHN. Neuroarthropathy in diabetes: pathogenesis of Charcot arthropathy. Bone Joint Res. 2018 Jun 5;7(5):373-378. eCollection 2018 May.
Hourston GJ, Barrett MP, Khan WS, Vindlacheruvu M, McDonnell SM. New drug, new problem: do hip fracture patients taking NOACs experience delayed surgery, longer hospital stay, or poorer outcomes? Hip Int. 2019 Apr 25:1120700019841351.[Epub ahead of print]
Devoy B, Yaghmour KM, Chisari E, McDonnell SM, Khan W. Perioperative management of renal transplant patients undergoing total joint arthroplasty. J Perioper Pract. 2019, Mar 19:1750458919835435
Palmer AJR, Ayyar Gupta V, Fernquest S, Rombach I, Dutton SJ, Mansour R, Wood S, Khanduja V, Pollard TCB, McCaskie AW, Barker KL, Andrade TJMD, Carr AJ, Beard DJ, Glyn-Jones S; FAIT Study Group. Arthroscopic hip surgery compared with physiotherapy and activity modification for the treatment of symptomatic femoroacetabular impingement: multicentre randomised controlled trial. BMJ. 2019, Feb 7;364:l185.
Tsekes D, Konstantopoulos G, Khan WS, Rossouw D, Elvey M, Singh J. Use of stem cells and growth factors in rotator cuff tendon repair. Eur J Orthop Surg Traumatol. 2019 Jan 9. [Epub ahead of print]
Tanase CE, Golozar M, Best SM, Brooks RA. Cell response to plasma electrolytic oxidation surface-modified low-modulus β-type titanium alloys. Colloids Surf B Biointerfaces. 2018 Dec 26;176:176-184. [Epub ahead of print]
Whitty, C., Wardale, J. and Henson, F.M.D. The regulation of sclerostin by caphepsin K in periodontal ligament cells. Biochemical and Biophysical Research Communications, 2018 Sep 5;503(2):550-555
Ranmuthu CDS, Ranmuthu CKI, Khan WS. Evaluating the Current Literature on Treatments Containing Adipose-Derived Stem Cells for Osteoarthritis: a Progress Update. Current Rheumatology Report. 2018 10;20(11):67 Review
Woods S, Barter MJ, Elliott HR, McGillivray CM, Birch MA, Clark IM, Young DA. miR-324-5p is up regulated in end-stage osteoarthritis and regulates Indian Hedgehog signalling by differing mechanisms in human and mouse. Matrix Biology. 2018 Sep 5. [Epub ahead of print]
Tcacencu, I., Rodrigues, N., Alharbi, N., Benning, M., Toumpaniari, S., Mancuso, E., Marshall, M., Bretcanu, O., Birch, M.A., McCaskie, A.W. and Dalgarno, K.W. Osseointegration of porous apatite-wollastonite and poly (lactic acid) composite structures created using 3D printing techniques. Materials Science and Engineering: C. 2018 Aug 90, 1-7
Duan, P., Toumpaniari, R., Partridge, S., Birch, M.A., Genever, P.A., Bull, S.J., Dalgarno, K.W., McCaskie, A.W. and Chen J. How cell culture conditions affect the microstructure and nanomechanical properties of extracellular matrix formed by immortalized human mesenchymal stem cells: An experimental and modelling study. Materials Science and Engineering: C. 2018 Aug 89, 149-159
Archer DE, Mafi R, Mafi P, Khan W. Preclinical Studies on Biomaterial Scaffold use in Knee Ligament Regeneration: A systematic review. Current Stem Cell Research & Therapy. 2018;13(8):691-701
Steinberg, J., Brooks, R.A., Southam, L., Bhatnagar, S., Roumeliotis, T.I., Hatzikotoulas, K., Zengini, E., Wilkinson, J.M., Choudhary, J.S., McCaskie, A.W. and Zeggini E. Rheumatology (Oxford). 2018 Aug 1;57(8):1481-1489
Arshad Z, Pettitt DA, Chadha P, Davies B, Carr A, Walmsley P. Artificial Intelligence to Predict Periprosthetic Joint Infection after Total Hip Replacement. International Journal of Surgery. 2018 July; 55:S8
Johnson-Lynn SE, McCaskie AW, Coll AP and Robinson AHN. Neuroarthropathy in diabetes: pathogenesis of Charcot arthropathy. Bone Joint Res. 2018 Jun 5;7(5):373-378
Ardakani AHG, Khan WS. The role of ageing and gender in musculoskeletal stem cell. Current Stem Cell Research & Therapy, 2018 13(6):432-437
Baird, A., Lindsay, T., Everett, A., Iyemere, V., Paterson, Y.Z., McClellan, A., Henson, F.M.D. and Guest, D.J. (2018). Osteoblast differentiation of equine induced pluripotent stem cells. Biology Open: May 7(5)
MacKay JW, Kapoor G, Driban JB, Lo GH, McAlindon TE, Toms AP, McCaskie AW and Gilbert FJ. Association of subchondral bone texture on magnetic resonance imaging with radiographic knee osteoarthritis progression: data from the Osteoarthritis Initiative Bone Ancillary Study. Eur Radiol. 2018 May 2. [Epub ahead of print]
Hodgson B, Mafi R, Mafi P, Khan WS. The Regulation of Differentiation of Mesenchymal Stem-cells into Skeletal Muscle: A Look at Signalling Molecules Involved in Myogenesis. Current stem cell research & therapy 2018 13(5), 384-407
Khan H, Mafi P, Mafi R, Khan W. The effects of ageing on differentiation and characterisation of human mesenchymal stem cells. Current stem cell research & therapy 2018 13(5), 378-383
Zengini E, Hatzikotoulas K, Tachmazidou I, Steinberg J, Hartwig FP, Southam L, Hackinger S, Boer CG, Styrkarsdottir U, Gilly A, Suveges D, Killian B, Ingvarsson T, Jonsson H, Babis GC, McCaskie A, Uitterlinden AG, van Meurs JBJ, Thorsteinsdottir U, Stefansson K, Davey Smith G, Wilkinson JM, Zeggini E. Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis. Nat Genet. 2018 Apr;50(4):549-558.
Khan WS. Outcomes of alveolar soft part sarcoma from a regional tumour unit. Acta Orthopaedica Belgica 2018 Apr [published online]
Khan S, Mafi P, Mafi R, Khan W. A Systematic Review of Mesenchymal Stem Cells in Spinal Cord Injury, Intervertebral Disc Repair and Spinal Fusion. Current stem cell research & therapy 2018 13(4), 316-323
Killington K, Mafi R, Mafi P, Khan WS. A systematic review of clinical studies investigating mesenchymal stem cells for fracture non-union and bone defects. Current stem cell research & therapy 2018 13(4), 284-291
MacKay JW, Low SBL, Smith TO, Toms AP, McCaskie AW. and Gilbert FJ. Systematic review and meta-analysis of the reliability and discriminative validity of cartilage compositional MRI in knee osteoarthritis. Osteoarthritis Cartilage. 2018 Mar 14. pii: S1063-4584(18)31069-0.
Borakati A, Mafi R, Mafi P, Khan WS. A systematic review and meta-analysis of clinical trials of mesenchymal stem cell therapy for cartilage repair. Current stem cell research & therapy 2018 13(3), 215-225
Lydon H, Brooks R, McCaskie A, Henson F. Peripheral mononuclear blood cell apheresis in a preclinical ovine model. BMC Vet Res. 2018 Feb 13;14(1):47.
Briggs W, Guevel B, McCaskie AW and McDonnell SM. Multi- and univariate analyses of the weekend effect for elective lower-limb joint replacements. Ann R Coll Surg Eng. 2018 Jan;100(1):42-46.
Kwon K-A, Juhasz JA, Brooks RA. Best SM. Bioactive conformable hydrogel-carbonated hydroxyapatite nanocomposite coatings on Ti-6Al-4V substrates. Materials Technology 2018. [published online]
Books and Chapters
Iyer K and Khan WS. (eds) (2020) Orthopedics of the Upper and Lower Limb. Springer, Cham.
Davies BM and Khan WS (2020) Stem Cell Therapy in Orthopedics. In: Iyer K., Khan W. (eds) Orthopedics of the Upper and Lower Limb. Springer, Cham. pp 565-572
Williams N, O’Connell PR and McCaskie AW (Editors) (2018). Bailey and Love: Short Practice of Surgery, 27th Edition. CRC Press
McCaskie AW and Bradley A (2018) Tissue Engineering and Regeneration Part 1: Basic Principles, ch.4, pp.33-41. In Bailey and Love: Short Practice of Surgery, 27th Edition. CRC Press
McDonnell SM and Pandit HG (2018) History taking and clinical examination in musculoskeletal disease. Part 5: Elective Orthopaedics, ch.31 pp.436-462. In Bailey and Love: Short Practice of Surgery, 27th Edition. CRC Press
Khanduja V and Khan W(2018) Hip and Knee Part 5: Elective Orthopaedics, ch.35 pp.511-523. In Bailey and Love: Short Practice of Surgery, 27th Edition. CRC Press
Seah MKT, Khan W (2018) Minimally Invasive Surgery of the Hip Joint. In Iyer, K. (Ed.) (2018) Hip Joint in Adults. New York: Pan Stanford. ch.5 pp.73-85
Seah MKT, Khan W (2018) Computer-Assisted Navigation of the Hip Joint. In Iyer, K. (Ed.) (2018) Hip Joint in Adults. New York: Pan Stanford. ch.6 pp.87-99